Hotels, Motels, Inns, B&B's, Resorts And Extended Stay in Wytheville, Virginia

There are 22 properties listed under Hotels, Motels and Extended Stay Suites in Wytheville available. All distances are from the center of Wytheville, so actual travel times may vary.


Photograph of Travelodge, Wytheville
Listing updated 2024
Hotel
Located 2 miles from the center of Wytheville. Your adventure begins at our Travelodge Wytheville hotel, conveniently located off I-77 and I-81. We are convenient to Roanoke Regional Airport (ROA) and minutes away from Wytheville Community College.
140 Lithia Road
Wytheville, Virginia
★★
705 Chapman Road
Wytheville, Virginia
Photograph of Red Roof Inn & Suites, Wytheville
Listing updated 2024
★★
Located 2 miles from the center of Wytheville. Red Roof Inn & Suites Wytheville in Virginia is a pet-friendly, family-friendly hotel situated in between Bristol and Roanoke.
1900 East Main Street
Wytheville, Virginia
Photograph of Days Inn, Wytheville
Listing updated 2024
Hotel
Located 2 miles from the center of Wytheville. Enjoy great value and warm hospitality at our Days Inn Wytheville hotel. Located at the intersection of I-81 and I-77 in the foothills of the Blue Ridge Mountains, our hotel near the Blue Ridge Parkway is ideal.
150 Malin Drive
Wytheville, Virginia
Located 1 mile from the center of Wytheville. Nestled in the Blue Ridge Mountains of Southwestern Virginia, this lovely home offers four elegant guestrooms plus a private garden cottage to provide the perfect setting for a small wedding, romantic celebration or a tranquil retreat from everyday life.
525 West Main Street
Wytheville, Virginia
Photograph of Ramada by Wyndham, Wytheville
Listing updated 2024
★★
Located 2 miles from the center of Wytheville. Enjoy your getaway to the foothills of the Blue Ridge Mountains at our Ramada Wytheville hotel. Our location at the intersection of I-77 and I-81, puts stunning scenery, outdoor recreation, and popular area attractions at your fingertips.
955 Peppers Ferry Road
Wytheville, Virginia
Photograph of Studio 6, Wytheville
Listing updated 2024
Extended Stay / Suite
Located 1 mile from the center of Wytheville. Find your home away from home comfort at our Wytheville motel near attractions such as dining and shopping and plenty of fun things to do in Wytheville.
1160 East Main Street
Wytheville, Virginia
Photograph of Hampton Inn, Wytheville
Listing updated 2024
Hotel
Located 2 miles from the center of Wytheville. Hampton Inn Wytheville, VA is easily accessible off of I-77. Book your stay today to experience exceptional service and free amenities..
950 Pepper's Ferry Road
Wytheville, Virginia
Photograph of Country Inn & Suites, Wytheville
Listing updated 2025
★★★★★★★★★
"Wonderful."
697 Peppers Ferry Road
Wytheville, Virginia
★★★★
Located 1 mile from the center of Wytheville. Let the destination reach you at The Bowling Wilson Hotel, An Ascend Hotel Collection Member hotel in Wytheville, VA located off Interstate 81 and 77 near Jefferson National Forest. This smoke-free, pet-friendly hotel is near attractions like Edith Bolling Wilson Museum, Thomas J.
170 East Main Street
Wytheville, Virginia
Photograph of Fairfield Inn & Suites, Wytheville
Listing updated 2024
★★
Located 2 miles from the center of Wytheville. The Wytheville Fairfield Inn and Suites by Marriott is nestled in the scenic Blue Ridge Mountains and conveniently located off I 77 and I 81, near popular attractions. NASCAR fans will enjoy our central location to Bristol Motor Speedway and Martinsville Speedway.
200 Marriott Way
Wytheville, Virginia
Photograph of Econo Lodge, Wytheville
Listing updated 2025
Hotel
Located 2 miles from the center of Wytheville. Guests of the Econo Lodge Wytheville will enjoy a complimentary continental breakfast daily and complimentary cookies each evening.
280 Lithia Road
Wytheville, Virginia
Photograph of Super 8, Wytheville
Listing updated 2024
Hotel
Located 2 miles from the center of Wytheville. Book a room at our pet-friendly Super 8 Wytheville hotel and get more out of your next trip. Our location off I-77 and I-81 makes it easy to get to the area's most popular attractions. The Wohlfahrt Haus Dinner Theatre is just five minutes from our hotel..
130 Nye Circle
Wytheville, Virginia
Located 2 miles from the center of Wytheville. The Rodeway Inn® Wytheville hotel is conveniently located off I-77 and I-81 at exit 73. Our location is just minutes from some of southwestern Virginia's most popular attractions, including the Wohlfahrt Haus Dinner Theatre, Edith Bolling Wilson .....
240 Lithia Road
Wytheville, Virginia
Photograph of La Quinta Inn & Suites, Wytheville
Listing updated 2024
Located 2 miles from the center of Wytheville. Join us at our charming La Quinta® by Wyndham Wytheville hotel. Located off I-81 and I-77, we put you close to plenty of adventures—whether you're a history buff or outdoor enthusiast.
1800 East Main Street
Wytheville, Virginia
Photograph of Tru by Hilton, Wytheville
Listing updated 2024
Located 2 miles from the center of Wytheville. When you're with us, you get to combine beautiful scenery with classic culture. We're minutes from hiking and biking trails, as well as the Claw of the Dragon motorcycle route. Museums and the Wohlfahrt Haus Dinner Theatre are eight minutes away and Big Walker Lookout is a short drive.
245 Boyd Avenue
Wytheville, Virginia
Photograph of Comfort Suites, Wytheville
Listing updated 2025
★★
Located 2 miles from the center of Wytheville. The Comfort Suites® allows you to be at your best while staying at our friendly hotel in Wytheville. Our spacious and cheery lobby—complete with sundry shop—will welcome vacationers and business travelers alike to a retreat designed for a great night’s rest and a great start to the day.
695 Peppers Ferry Road
Wytheville, Virginia
Photograph of Holiday Inn Express, Wytheville
Listing updated 2024
★★★
Located 2 miles from the center of Wytheville. We are conveniently located right off I-81 & I-77 at Exit 73..
165 Malin Drive
Wytheville, Virginia

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