Places to stay in Santee, South Carolina

Santee is a town in Orangeburg County along the Santee River Valley in central South Carolina of the United States. It has become a resort town of note located centrally north-south along the Atlantic Seaboard of South Carolina. The region has been rural, with a primarily agricultural economy typical of Orangeburg County, but it is now known primarily for its several golf courses in proximity to Lake Marion, Santee State Park and other Lake Marion attractions. Interstate 95 connects its attractions easily with tourists' traveling by automobile. I95 crosses a narrow arm of the lake into the town lands, along a picturesque causeway. Lake Marion is a man-made hydroelectric reservoir, which at 110,000 acres is one of the fifty largest lakes in the country. Local restaurants include Shoney's, Maurice's Gourmet Barbeque, Maurice's Piggie Park BBQ, and Coasters Bar & Grill.

If you are travelling in the area, Santee is located close to Cantey Bay, Days Inn Summerton Sc, Travelodge Santee, Santee School (historical) and Town of Eutawville.

The center of Santee ( which is at is longitude -80°29'13.2 and latitude 33°28'48.72 ) is located 5 miles away from Vance and 7 miles away from Elloree.

Available Santee lodging

We currently have 24 accommodations in and around Santee.

Santee Hotels, Motels, Resorts, B&Bs and Extended Stay

Photograph of Holiday Inn Santee, Santee
Listing updated 2024
Hotels

Holiday Inn Santee

Santee Hotel's Address Convenient to Lake Marion Going fishing or golfing? The Holiday Inn Santee hotel is perfect for both recreational activities. Just off I-95 in Santee, SC, our hotel's location is less than an hour from both Columbia and Charleston, two unique cities to visit for a day trip.
139 Bradford Boulevard
Santee, South Carolina
Photograph of Comfort Inn, Santee
Listing updated 2024
Hotels

Comfort Inn

If your idea of a vacation or getaway involves lakes, golf, hiking and sunshine you’ve found the perfect option. Of course, we can’t guarantee the sunshine.
221 Britain Street
Santee, South Carolina
Photograph of Rodeway Inn, Santee
Listing updated 2024
Hotels

Rodeway Inn

Our amenities and convenient location make the Clarion® Inn Santee I-95 a natural choice for families, groups and business travelers. Whether you’re here for work or play, the area’s fresh air and outdoor splendor will entice you.
123 Mall Street
Santee, South Carolina
Photograph of Red Roof Inn, Santee
Listing updated 2024
Hotels

Red Roof Inn

We are one of the best budget hotels in Santee, SC, a year-round golf destination commonly referred as “America’s Value Golf Destination.” We are close to the beautiful greens at Lake Marion Golf Course and Santee Cooper Country Club.
9091 Old Number Six Highway
Santee, South Carolina
Photograph of Quality Inn, Santee
Listing updated 2024
Hotels

Quality Inn

At our Quality Inn & Suites® in Santee, SC, you can rest assured that we plan to give you a hotel experience that provides you the value you deserve. Friendly service that serves up free hot coffee and free hot breakfast every morning, helping you get ready to take on the day..
8929 Old Number Six Highway
Santee, South Carolina
Photograph of Hampton Inn, Santee
Listing updated 2024
Hotels

Hampton Inn

Discover how Hampton Inn Santee-I-95 is unique among Santee, SC hotels. Located within walking distance of the outlet mall, we offer free WiFi and breakfast.
9060 Old Number Six Highway
Santee, South Carolina
Photograph of Tru by Hilton, Santee
Listing updated 2024
Hotels

Tru by Hilton

At our Tru by Hilton Santee hotel, enjoy free breakfast and WiFi plus a lively lobby with work space, a game zone, and 24/7 market..
273 Britain Street
Santee, South Carolina
Hotels

Clarks Inn

In the heart of Santee, South Carolina, this historic Inn & Restaurant hasn't lost any of its charm since first opening in 1946.
114 Bradford Boulevard
Santee, South Carolina
Photograph of Baymont by Wyndham, Santee
Listing updated 2024
Hotels

Baymont by Wyndham

You’ll appreciate the comforts and conveniences of home at Baymont by Wyndham Santee, off US-15 with easy access to I-95 and 60 miles from Charleston International Airport (CHS). Visit Santee Welcome Center for information on attractions like Lake Marion and Santee State Park.
249 Britain Street
Santee, South Carolina
Photograph of Travelodge, Santee
Listing updated 2024
Hotels

Travelodge

Adventure awaits at Travelodge by Wyndham Santee, conveniently located off exit 98 on I-95. Our cozy hotel sits in central South Carolina, close to Lake Marion. Discover hiking trails and fishing at Santee State Park or head to the Santee National Wildlife Refuge for even more outdoor fun.
9117 Old Number 6 Highway
Santee, South Carolina
Photograph of Super 8, Santee
Listing updated 2024
Hotels

Super 8

Make our Super 8 Santee hotel your home base for golf and recreation in South Carolina. Located off I-95, halfway between New York City and Miami, our hotel is a comfortable stopping point on your East Coast road trip..
9125 Old Highway 6
Santee, South Carolina
Photograph of Econo Lodge, Santee
Listing updated 2024
Hotels

Econo Lodge

Our Econo Lodge® in Santee near Parris Island is easy to find, easy to book and easy on your wallet. Conveniently located along the Santee River Valley in the heart of one of South Carolina’s premiere golfing destinations, our discount hotel makes travel easy with generous amenities.
9112 Old Number 6 Highway
Santee, South Carolina
Hotels

Best Western Santee

Conveniently located off I-95, this Santee hotel offers cozy guest rooms and easy access to area attractions, including golf courses and state parks.
Interstate 95
Santee, South Carolina
Hotels

Lake Marion Golf Villas

Santee Cooper Golf features 2 championship golf courses located less than a 3-wood away from Interstate 95 in South Carolina. Historically known for its convenience and great value, Santee Cooper Golf provides golfers with well manicured conditions and great service.
9069 Highway #6
Santee, South Carolina
Hotels

Fairfield Inn & Suites

The Fairfield Inn and Suites is Santee South Carolina only Marriott, providing gracious hospitality for a relaxed and comfortable stay for you and your Pets. The hotel has easy on off access to I 95 highway at exit 98 for you, we offer travelers .....
9074 Old Number Six Highway
Santee, South Carolina
Hotels

Santee State Park

251 State Park Road
Santee, South Carolina
Hotels

Lake Marion Inn

628 Bass Drive
Santee, South Carolina
Motels

Budget Motel

514 Bass Drive
Santee, South Carolina
Hotels

Mansion Park

656 Bass Drive
Santee, South Carolina
Hotels

Days Inn

9074 Old Highway # 6
Santee, South Carolina

Santee Camping & RV, Cottages, Rentals and Lodges / Ranches

Vacation Rentals

Chapel Creek Plantation At Santee National Golf Club

With excellent accommodations, magnificent golf courses, and true southern hospitality all nestled in the heart of the beautiful South Carolina Lowcountry, it’s no wonder that Santee has become a golfer’s preferred vacation destination.
155 Myrtlewood Drive
Santee, South Carolina
Vacation Rentals

Lake Marion Resort & Marina

510 Ragtime TRL
Santee, South Carolina
Vacation Rentals

Era Wilder Realty

250 Plaza CIR
Santee, South Carolina
Vacation Rental
9355 Highway 6
Santee, South Carolina
Booking.com

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Renamed properties