Places to stay in Depew, New York

Depew is a village in Erie County, New York. It is part of the Buffalo–Niagara Falls Metropolitan Statistical Area. The name is derived from Chauncey Mitchell Depew, the President of the New York Central Railroad and former US Senator. Local restaurants include La-Castelana Pizzeria & Restaurant, Galveston Steakhouse & Pub, The Yelling Goat, and Frenchview Family Restaurant.

If you are travelling in the area, Depew is located close to Bethlehem Park School, Hampton Inn Buffalo-Williamsville, NY, Daemen Hall, Black Rock Canal and Buffalo Zoological Garden.

The center of Depew ( which is at is longitude -78°41'29.4 and latitude 42°54'15.12 ) is located 2 miles away from Lancaster, 3 miles away from Bowmansville, 4 miles away from Cheektowaga and 5 miles away from Williamsville.

Available Depew lodging

We currently have 6 accommodations in and around Depew.

Depew Hotels, Motels, Resorts, B&Bs and Extended Stay

Photograph of Holiday Inn Express Cheektowaga North East, Cheektowaga
Listing updated 2026
Hotels

Holiday Inn Express Cheektowaga North East

Approx 5 miles away in Cheektowaga:

There are various sport venues close by such as Riverworks, Holiday Twin Rinks, Leisure Rinks, Cazenovia Ice Rink, and Northtown Center. Relax at our indoor heated salt water pool and check out our fitness center.
83 Anderson Road
Cheektowaga, New York
Hotels

Best Western Buffalo Inn & Suites

Approx 4 miles away in Buffalo:

Welcome to Best Western Buffalo Inn & Suites, your modern retreat in the heart of Western New York.
50 Freeman Road
Buffalo, New York
Extended Stay / Suites

Residence Inn

★★★★★★

Approx 5 miles away in Cheektowaga:

Searching for an all-suite, extended stay buffalo hotel near Buffalo Niagara Airport? Residence Inn Buffalo Galleria Mall is the premier choice of hotels in Buffalo for corporate, leisure and group travel. Our spacious Buffalo hotel offers one .....
"It is great to have the small kitchen in the room for use. This allows for food to be kept and not having to rely on restaurants all the time. Having the hotel close to the highway and great shopping ..... "
107 Anderson Road
Cheektowaga, New York
Hotels

The Delavan Hotel And Spa

The Delavan Hotel is a 60 room boutique hotel and spa that is elegantly equipped with all the amenities you could ask for during your stay. We have an onsite fine dining Italian steakhouse called Salvatores Italian Gardens that is one of Buffalo .....
6461 Transit Road
Depew, New York
Motels

Pink Fountain Motor Inn

5474 Transit Road
Depew, New York

Depew Camping & RV, Cottages, Rentals and Lodges / Ranches

Camp Good Days & Special Times

Campsite / RV Park
6430 Transit Road
Depew, New York
Booking.com

Other useful links:

Things to see and do, places to eat in Depew

Photograph of Teton Kitchen Thai & Japanese Cuisine, Cheektowaga
Teton Kitchen Thai & Japanese Cuisine

Teton Kitchen Thai & Japanese Cuisine ( Dining / Thai ). Located at 415 Dick Road, Cheektowaga, 3 miles from the center of Depew. Chef & owner Taka who’s originally born in Japan knows how to take care of Japanese and Thai cuisine with over 10 years of experience. He worked in Izuei Kabayaki restaurant in Nagata Cho, Tokyo, Japan for 7 years and was a sushi chef in the States for almost 4 years before opening Teton Kitchen in 2013. tetonkitchen.com Link