Places to stay in Charleston, Missouri

Charleston is a city in Mississippi County, Missouri. It is the county seat of Mississippi County. Local dining options include Willie Mae’s Wings And Things, Wally’s, City Limits Grill, and Waffle & Pancake House.

If you are travelling in the area, Charleston is located close to Washington Avenue Baptist Church, Otter Pond, Blodgett School (historical), Cairo Airport and Saint Pauls Church.

Available Charleston lodging

We currently have 4 accommodations in and around Charleston.

Charleston Hotels, Motels, Resorts, B&Bs and Extended Stay

Photograph of Super 8, Charleston
Listing updated 2024
Hotels

Super 8

Our Super 8 by Wyndham Charleston/Sikeston East MO hotel is conveniently located off I-57 and Highway 60, just 35 miles from both Cape Girardeau Regional Airport (CGI) and Barkley Regional Airport (PAH). We're near Sikeston and within driving distance of St.
310 South Story Street
Charleston, Missouri
Hotels

Eagle Inn Charleston

Ideally located right off Interstate 57, the Eagle Inn Hotel is perfect for business and leisure travelers. We are located less than 30 miles from Towosahgy State Historic Site and Big Oak Tree State Park. The Hotel is a few miles from the mighty Mississippi River.
2811 East Marshall Street
Charleston, Missouri
Hotels

Quality Inn

Easy access to I-57 & I-55. FREE use of nearby health club. FREE high speed Internet access in all rooms, lobby, and breakfast area. The hotel offers a FREE HOT BREAKFAST. Pet Accommodation: 12.00 per night per pet. Pets up to 50lbs. only..
102 Drake St. I-57 ex. 10
Charleston, Missouri

Charleston Camping & RV, Cottages, Rentals and Lodges / Ranches

Campsite / RV Park
I-57 at Exit 10
Charleston, Missouri
Booking.com

Other useful links:

Renamed properties