Places to stay in Cairo, Illinois

Cairo is a city in Alexander County, Illinois in the United States. It is the county seat of Alexander County. Cairo is located at the confluence of the Mississippi and Ohio Rivers, and is the southernmost town in the state of Illinois. The rivers converge at what is the southernmost point in Illinois at Fort Defiance State Park, an American Civil War fort that was commanded by General Ulysses S. Grant, making Cairo the only city in Illinois completely surrounded by levees. Local dining options include Shemwell's BBQ, Kentucky Hillbilly BBQ, Indian Hills Trading Post, and River City Diner.

If you are travelling in the area, Cairo is located close to Ward Chapel African Methodist Episcopal Church, Cane Island, Church of God, Minor Lake and Liberty Church.

Available Cairo lodging

We currently have 3 accommodations in and around Cairo.

Cairo Hotels, Motels, Resorts, B&Bs and Extended Stay

Photograph of Quality Inn, Cairo
Listing updated 2024
Hotels

Quality Inn

Quality Inn Cairo Mounds is located off of Interstate 57 near the tri-state borders of Illinois, Missouri and Kentucky. This cozy and relaxing hotel is located minutes from where two mighty rivers meet- the Ohio and the Mississippi, making it a .....
13201 Kessler Road Route 3 and I-57
Cairo, Illinois
Motels

Belvedere Motel

3901 Sycamore Street
Cairo, Illinois
Motels

Garden Inn Motel

Rt. 37 North
Cairo, Illinois

Cairo Camping & RV, Cottages, Rentals and Lodges / Ranches

We currently have no listings available in this category. If you own a relevant property and would like it listed please use the submission form

Booking.com

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Renamed properties